For me, even the neck pickup placement of a 24 fret guitar makes the pickup unpleasantly and 'tubby' and 'boomy' sounding, a sound i consider unusable on its own, each pickup should have a tone usable on its own. I prefer pickups closer to the bridge like on some metal guitars. I have unconventional and untraditional tastes. Requiring the neck pickup close to the highest frets messes up the design of the neck joint and messes up high fret access. It pushes the neck joint out under the high frets and weakens the neck joint by removing structural material.