I have it and use it for my system audio and for amp sims in REAPER as I don't own a physical amplifier. While the interface originally advertised a buffer size of 64 samples, Steinberg has implemented support for 32 samples through driver updates. That said, and while it's not the purpose of the thread, I prefer it at 64 samples when doing something more intensive on the whole system like gaming. 32 samples works pretty much only in DAW for me, be it with a Intel i5-6600K (16GB DDR4 3000-CL15) or an AMD R5-3600 (16GB DDR4 3600-CL16 memory). When multi-tasking at 32 samples, I tend to have audio dropouts: the audio just dies for a couple of seconds and comes back. Aside from that, I think it's fine. It wasn't built for 32 samples of latency, but I don't have much to complain about otherwise. You won't turn the Input Gain knob very high, but Gain on an interface is like Gain on an amp: higher isn't better, and you're not necessarily missing out on something just because you can't turn the gain very high. That said, for the same price and if I had to buy an interface today, I probably at least would try a Behringer UMC404HD. The price is way too good to not at least try it, and the reviews seems rather positive. It also has more features; I kinda regret not having two high impedance inputs on my UR22MkII to switch between instruments seamlessly. Other than that, a DI box is most likely the way to go with such interfaces if you're really worried about the preamp quality.