I started tuning to D standard ~20 years ago. It's still, in theory, my favorite tuning, but a few years ago the sound of plain steel strings above .017" started bothering me. Now I can't bare to play them and even the .017" (and .016) is starting to bother me. I recently bought some NYXLs to see if the steels were really different. Perhaps they are, but they still lack stability (not tuning stability but resonant stability). The area from the 9th to 15th with a neck pickup used to produce my favorite tone, now I'm almost never using neck pickups. The warbling tone I get from this string and especially this region of it on ANY guitar with ANY pickup is just repulsive to me. I can only stomach it on a 26.5" B standard 7 with a .015 G right now and I'm afraid that's changing. A lot of this is me and my apparently evolving tastes (which, problematically, aren't just evolving but disappearing, meaning I have no reasonable assonant substitute despite really being into the Mark IV tone I've always loved on the other strings), but some of it is objective. Plain steel strings are increasingly unstable as mass increases. Wound strings aren't as bendable even at equal tension. In my opinion, being able to use a small third string is the only good argument for E standard being the standard tuning as I find C and D far more practical and pleasant. Does the plain G really bother anyone else? I'm not sure what I can do about this. It's with any amp and any guitar at this point. :/ I think a lot of leads in the studio are played on guitars tuned to E standard and/or with small strings for good reason.