I've experienced a great deal of wrist pain and general discomfort in my time playing guitar. I dunno if its the same kind of pain you're experiencing, but maybe the solutions I found for myself can help you too: First and foremost- my guitar needs to be well-balanced. My first guitar was TERRIBLE in this respect, and as a result, one morning after practising I woke up with my fretting hand almost completely numb and I couldn't grip anything all day. It healed after a day or two, and I can thankfully play just fine now, but even to this day it feels a little numb sometimes. Fretting quickly is a difficult enough task for your hand without also forcing it to hold your neck upright, and sadly, even a Strat-shaped guitar isn't perfect. You're gonna want to make sure it stays put. For this, a leather strap goes a long way. Doesn't have to be super-wide as long as it grips your shoulder well. Of course, some guitars really can't be helped, so I'd say avoid anything with severe neck dive regardless. Second, I no longer try to force myself to "get used to" a neck. I have rather small hands. As I've discovered, this means playing those wide, flat Ibanez/Jackson style necks is a bad idea. Even if I keep my guitar strapped pretty high up I still hurt myself trying to wrap my hand around one of those things. My LTD EC, though, with its nice 42mm wide C-shaped neck, fits perfectly in my hand. I'm even playing slung down at Punk Rocker height and it feels fine. Sadly, though, this means I'm using my seven string a lot less, but as time has gone by, I've begun to truly appreciate what can be done with a measly six... not to mention, for a gearhead like myself, there's a LOT more options for parts available than there exist for any ERG. But, I can still use it sparingly for a song or two without hurting myself. Bottom line, you need to find something that feels comfortable in your hand. Maybe you're like me and need something smaller, or maybe you just need a chunkier neck that you can wrap your hand around instead of a flat plank... or maybe a flat plank is exactly what you need and you just don't have one yet! Experiment a little with different guitars. Do some research into what widths, profiles and scale lengths tend to feel best to you, and go from there. Hopefully that helps.