Fuck no. For this reason: + You're relying on the sound guy having the faintest idea what they're doing. Most of the time they don't. There's a lot of posts here that sound like they're coming from people who don't play live all that much. Not all PAs are equal, running guitar through a PA is something I avoid if I can help it, it just adds more ways for the sound to be fucked with. An angled 2x12 is an improvement over a regular one, I've played with SO MANY bands who get their tones ready with a straight 2x12 or 4x12 while they're listening stood up, so you end up listening to this really piercing trebly sound out front. Horrible. Lugging around a 4x12 is a piece of cake if you're touring in a van. Half the time you won't even be using it (if you don't want to) because there'll be house cabs or other bands to share with, and if you're touring with other bands you generally gear pool so lugging it out of the van and into the venue is a shared task. Not that taking gear in and out of vans is that bad. There are people in their 40s who mine coal or move furniture or boxes 12 hours a day for a living, moving a 4x12 is not that bad unless your back is fucked or something.