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EL34 mode. They stress the grid resistors and PT more than EL34s or 6L6s, but a Mesa should handle them well. Keep it in tube rectifier...
Since you already have an interface, AX8 all the way. Easy as hell to go live whenever you decide to gig it.
FB w/ P50Es here, super tight bass. You do have to crank up your amp though, they compare more favorably to other cabs at high volumes.