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The computer can and will effect latency, a top spec custom built system will of course have the processing power and memory to avoid bottlenecking your setup, while a slower machine might not have enough headroom and processing takes longer. This is probably more applicable on the low budget scale, as you will be relying on software to do the jobs outboard hardware could do better and without use of system resources. The Line6 is a common solution, but I'd look at some of the non-consumer-grade sound cards available too, they can be had for not too much, many include free software like protools light, and you will get extra functionality.
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