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Great discussion! I use light strings 9-54 which is relatively loose, yet pick fairly aggressively, as I like to really beat up the strings when I play. I love the sound of really hearing the strings get abused and bent around. With lighter and looser strings you have more control over intonation, which can help or hurt your tone. You have to be a bit more careful how hard to press down on the frets as a note can go sharp. Properly controlled, this can give your sound more character.
I'm somewhat from the old school of Van Halen style, but 7 string all the way. Eddie's trademark sound was in part using light strings tuned down (very loose and slinky) yet he picked very aggressively with his fan picking technique. Lots of attack and great intonation.
my two cents....
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