Did you stretch the strings properly when you put them on? Letting the guitar sit, or playing it, will not stretch the strings out. I would get at least 1-2 wraps around the tuner, so you can actually stretch the strings. Having no wraps does not eliminate the stretching issue.
Did you reset the trem's angle when you went to the larger gauge? An out of balance floyd can go out of tune.
Is it sticking? If you push the bar down, and get the guitar in tune, does it stay in tune after dives, but go sharp after pull-ups? This would be the knife edges being dull, or the studs having a bur or flat spot.
Lots of set-up and restringing info for Ibanez guitars here:
IBANEZ RULES!! tech - setup