The 7521 I used to have was an awesome guitar. I'd still have it if I didn't need the money at the time. I can't speak for the 7221s, but I liked the neck on the 7521, the neck pickup was pretty sweet too.
Ibanez RG7421XL w/ DiMarzio Evolution and Liquifire
Ibanez K7WH w/ DiMarzio Evolution
Ibanez RG7321BK w/ Blaze Custom
Agile Intrepid Pro 828 w/ EMG808
My band Scarangella