Neither one is really what I would call better than the other. I've a/b both with my 5150 II and I prefer the orange, but the mesa still sounded great. Just don't get an oversized mesa cab or the open back orange and you should be fine.
"At least Deathcore was heavy as shit when done right, this new stuff sounds like if meshuggah and taking back sunday had a homosexual he/she creature when bred together." -- Some dude on youtube