^ True. I've thought about it before when playing guitar, even, and it's my only problem with drop tuning. That said, I don't really tend to do runs on the bottom strings.
I guess it definitely depends on your playing style.
I'm soon getting a guitar in EA EADGBE tuning, and my playing style is illustrated there. No runs on the bottom strings, just played like a 6 string guitar with octaves available at the same fret. I guess my bass playing is similar as I tend to follow the guitar on anything involving low strings. Unique lines I tend to always play much higher.