My main tuning is dropped B. Thats what I write in. My band covers a few Slipknot tunes. However, I find myself having different guitars for different songs, due to tuning differences. I have found that I can change the fingering on the drop B toplay other songs. As an example, we cover Made of Scars (which is in a drop D flat), I play this on my drop B, the chord is fingered at the 7th fret for me, not the 5th (I think it was originally). Its just a fast jump to hit the nots at the second fret, that would normally be open.
If your reading tab, you'll have to transpose it for the tuning your in. Some times it can be challenging, but fun. I hope I didn't confuse you, I know I am.