What sixes are you playing? I have giant hands and I find both equally comfortable. My futura has the same neck profile as an ibanez wizard 2 neck and I have no problem switching between that, to my strat copy with a beefy C strat neck, and my 7 douglas with a very thin U profile (almost, if not the same size as my old ibanez RG7620 neck.. badass stuff, being I only paid 190 dollars for the douglas!).. though at first I'd have a problem with my hand cramping up. Just play all of them evenly as mentioned and you should be fine
